The Impact of Strontium Ranelate on Implant Osseointegration of Osteoporosis in Vivo Experiment
نویسندگان
چکیده
Objective: To investigate the impact of strontium ranelate on implant osseointergration of osteoporotic rats in vivo experiment. Method: Thirty-six female rats were randomly divided into three groups: ovariectomization group (A=12), strontium ranelate low-dose treatment group (B=12) and strontium ranelate high-dose treatment group (C=12). After the success of the osteoporosis model building, HA coated titanium implants were inserted into proximal metaphyses of tibiae, meanwhile, the rats of group B and C received oral medication of strontium ranelate (B: 450 mg/kg.d C: 900 mg/kg.d), 12 weeks after surgery, animals were killed and decalcified sections were prepared and examined histologically and histomorphometrically, as well as micro-CT examination. Results: 12 weeks after implantation surgery, Bone Mineral Density (BMD), Implant Bone Contact Rate (IBCR) and New Bone Volume (NBV) in group B and C were significantly higher compared with group A (p<0.01). Conclusion: Strontium ranelate may resist the negative influence of osteoporosis and promote osseointergration of implant.
منابع مشابه
Suspecting hypophosphatemic osteomalacia we obtained the following test results in search of its etiology: normal serum protein on electrophoresis with absence of Bences Jones protein in the urine, normal tumor markers (carcinoembryonic antigen
1. Albrektsson T, Johansson C. Osteoinduction, osteoconduction and osseointegration. Eur Spine J. 2001;10 Suppl. 2:S96–101. 2. Reginster JY, Seeman E, De Vernejoul MC, Adami S, Compston J, Phenekos C, et al. Strontium Ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis Treatment Of Peripheral Osteoporosis (TROPOS) stydy. J Clin Endocrinol Metab. 2005;90...
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